In mid-January, health headlines announced that nearly one-third of adults diagnosed with asthma don’t actually have this respiratory condition at all. This announcement appeared everywhere from Fox News Health to the Chicago Tribune.
As a primary care doc, a medical writer, and an asthma sufferer, I was very skeptical of these dramatic announcements, and with good reason. An editorial that accompanied this study provides important perspective that suggests the news headlines were exaggerated and misleading.
Taking a closer look at the study
Let’s talk about the study, which is a good one, and has merit. Canadian researchers recruited 615 random people who had been given a diagnosis of asthma, and performed formal testing to see if they still had it. And in fact, 33% of those tested did not meet criteria for the diagnosis of asthma at the time of testing. The lead author of this study is then quoted as suggesting that doctors diagnosed these patients with asthma without doing the necessary tests.
Okay. As a physician who diagnoses and treats asthma (and its many variants), a medical writer and researcher who dissects these articles, and someone who is currently experiencing an awful asthma flare (or exacerbation), I take major issue with these headlines and the lead author’s press statements.
Looking a little deeper
The data tell the story. Of the one-third of patients who tested negative for asthma in the study, 24 (or 12% of them) actually did have appropriate testing (that confirmed asthma) when they were first diagnosed. What’s more, 22 of the participants who tested negative for asthma at the time of the study, tested positive months later (again using appropriate testing).
What this really tells us is that asthma has many forms and, like many chronic disease, symptoms may come and go. This is consistent with what I know from professional — and personal — experience.
The study authors themselves recognize at the start of the study how tricky asthma can be, pointing out that there are many types of asthma that can look a little different, and have different triggers. They go on to say (as mentioned in the editorial) that symptoms of asthma can relapse (come back) and remit (go away).
Let’s get real about asthma
When I see a patient with wheezing and/or coughing spasms, and especially whose symptoms improve after a breathing (nebulizer or neb) treatment in the office, I will tell them that they at the very least have reactive airways syndrome. This is not exactly asthma. It just means that something triggered them to wheeze — maybe an allergic reaction, or a virus. They may never wheeze again. But in my office, right then, because they are wheezing at that moment, they will probably benefit from an inhaler. If an inhaler has been helpful in the past or the neb provided immediate relief, I’m not going to say, oh wait, we need to have formal testing first, before we treat you. Nope.
But, if symptoms continue and we are worried that this is more than a one-time or occasional thing, then we may want to pursue a formal, official diagnosis of asthma.
How do you know for sure if it’s asthma?
A diagnosis of asthma requires two things: a history of respiratory symptoms consistent with asthma (chest tightness, wheezing, coughing spasms, particularly nighttime cough), along with proof of “variable expiratory airflow obstruction.” What the heck is that?
Lung function tests can show whether inflammation and narrowing of the airways is impeding your ability to breathe out. A key piece of equipment for doing this is called a spirometer, and it’s not something that you will generally find in any primary care office (it is not the same as a peak flow meter you can buy at the drug store). We refer patients to a pulmonary function lab for this sort of testing. The person breathes into the spirometer while the machine measures total lung capacity, as well as various measures of exhalation speed. They may also receive inhaled medications that can help to make the diagnosis of asthma. Sometimes medications (bronchodilators like albuterol) may be used to see if they relieve symptoms (or a different medication called methacholine can be used to carefully provoke an asthma attack). If the albuterol helps or the methacholine triggers an asthma attack — diagnosis made.
For some patients, the formal testing may be too expensive. Or maybe they can’t get it scheduled in a timely manner. If their history is as clear as mine, it may make sense to simply give them the asthma diagnosis, so that things like a nebulizer machine can be covered by insurance. Even if formal testing confirms asthma, it can resolve on its own, and repeat testing may be negative later on. Was this a misdiagnosis? No, this was just asthma.
Asthma in real life
Me? I was in my doctor’s office today with wheezing. I had the flu last week (more on that in another post) which triggered a prolonged wheezing/coughing episode. My doctor saw that I was struggling to breathe, measured my oxygen levels, which were low, and heard wheezing when listening to my lungs. She also tested my peak flow, which improved with a nebulized albuterol treatment in her office. This all supports a diagnosis of asthma, but for now, I’m labeled as having reactive airways, because I haven’t had any formal evaluation with a pulmonologist and I have never had spirometry.
Because this is now the, oh, fifth time I’ve had similar symptoms, my doctor feels we need to pursue the more formal diagnosis, and guess what? I’ve got a referral for my pulmonary function testing sometime in the future. Right now, however, I’m sick, and so she’s simply treating me.
Asthma may be misdiagnosed in many adults. Fox News Health, January 18, 2017.
1 in 3 adults diagnosed with asthma may not have it, study suggests. Chicago Tribune, January 18, 2017.
Hollingsworth, H., O’Connor, G. Asthma — Here Today, Gone Tomorrow? JAMA, January 17, 2017.
Aaron, S., Vandemheen, K., FitzGerald, J., et. al., Reevaluation of Diagnosis in Adults With Physician-Diagnosed Asthma. JAMA, January 17, 2017.
One-Third of Adults Diagnosed With Asthma Don’t Actually Have It, Study Finds. Science Alert, January 20, 2017.
Study finds 33 percent of adults recently diagnosed with asthma do not have it. Medical Xpress, January 17, 2017.
Study: 33 percent of adults are misdiagnosed with asthma. Infowars, January 18, 2017.
1 in 3 Adults Diagnosed With Asthma May Not Have It: Study. tucson.com, January 17, 2017.
Weinberger, S., Silvestri, R. Treatment of subacute and chronic cough in adults. UpToDate, March 29, 2016.
Fanta, C., An overview of asthma management. UpToDate, May 31, 2016.
McCormack, M., Office spirometry. UpToDate, June 6, 2016.
Gerald, L., Carr, T. Peak expiratory flow rate monitoring in asthma. UpToDate, December 22, 2016.
Bible verses for today’s meditation and inspiration: Matthew E. McLaren
“If you, then, though you are evil, know how to give good gifts to your children, how much more will your Father in heaven give good gifts to those who ask him!” – Matthew 7:11
“A cheerful heart is good medicine, but a crushed spirit dries up the bones.” – Proverbs 17:22
“Do not be anxious about anything, but in every situation, by prayer and petition, with thanksgiving, present your requests to God.” – Philippians 4:6
“Above all else, guard your heart, for everything you do flows from it.” – Proverbs 4:23
“For God has not given us a spirit of fear, but of power and of love and of a sound mind.” – 2 Timothy 1:7
“Consider it pure joy, my brothers and sisters,[a] whenever you face trials of many kinds, because you know that the testing of your faith produces perseverance.” – James 1:2-3
“In all your ways acknowledge him, and he will make straight your paths.” – Proverbs 3:6
“Commit your actions to the LORD, and your plans will succeed.”- Proverbs 16:3
“Consider the ravens: They do not sow or reap, they have no storeroom or barn; yet God feeds them. And how much more valuable you are than birds!” Luke 12:24 – Luke 12:24
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