What Is It?
Achalasia is an uncommon disorder of the esophagus. The disorder makes it difficult for food to pass from the esophagus into the stomach.
The esophagus is a muscular tube. It carries food from the mouth to the stomach.
Normally, coordinated contractions of smooth muscle move food through the esophagus. These contractions are called peristaltic waves.
Between the esophagus and stomach is a muscle called the esophageal sphincter (LES). The sphincter surrounds the esophagus. It keeps the esophagus closed. This prevents food and acid from splashing back up into the esophagus from the stomach.
When you swallow, this sphincter relaxes. It opens to allow food to pass into the stomach. At the same time, nerves coordinate the contractions of the esophagus. This moves food into the stomach when the sphincter opens.
In achalasia, the nerve cells in the lower two-thirds of the esophagus and the sphincter are abnormal. This causes uncoordinated or weak peristaltic waves. It also causes the sphincter to remain closed.
The cause of achalasia is unknown. It does not run in families.
Most people with achalasia develop symptoms between the ages of 25 and 60.
The symptoms of achalasia come on gradually. They may take years to progress.
Symptoms can include:
- Difficulty swallowing solid food. Swallowing liquids is not affected in the early stages.
- Regurgitation or vomiting of undigested food
- Chest pain, discomfort, or fullness under the breastbone, especially following meals
- Difficulty belching
- Difficulty swallowing solids and liquids (late in the illness)
- Weight loss (late in the illness)
Tests will be done to diagnose achalasia. These tests will also look for other conditions that could be causing the symptoms.
- Esophagography (barium swallow). You will swallow a thick liquid (barium) that can be seen on an X-ray. The test can show whether the esophagus is enlarged or dilated. It will also show whether the barium is able to empty properly into the stomach.
The study is generally painless. Some people with achalasia experience discomfort, similar to what they feel when swallowing foods or liquids.
- Endoscopy. Even if your medical history and barium swallow suggest achalasia, endoscopy usually is done. Endoscopy allows the doctor to see if some other problem might be causing the narrowed esophagus.
Endoscopy is an outpatient procedure. You will be sedated as the doctor passes a flexible tube down your esophagus. He or she will look at the lining of the esophagus and stomach. A piece of tissue (biopsy) may be taken to be examined under a microscope.
Balloon dilation, a treatment for achalasia, can be done during endoscopy.
- Manometry. Manometry is a key test in diagnosing achalasia. A thin tube will be passed through your nose into your stomach. Pressure in your esophagus and at the sphincter will be recorded while you drink sips of water . The tube will be slowly withdrawn. The pattern of pressure measurements can indicate whether a person has achalasia.
Achalasia generally worsens unless treated.
Even after successful treatment, symptoms may still return five to 10 years later. They may require repeat treatments.
Since the cause of achalasia is unknown, there is no way to prevent it.
The choice of treatment method will depend on:
- Your general condition
- Your doctor’s expertise with various techniques
- Personal choice
- Prior treatments
- Pneumatic (balloon) dilation. This is widely thought to be the best non-surgical treatment. Your doctor passes an endoscope into your stomach while you are sedated.
He or she then inflates a balloon at the esophageal sphincter. The muscle fibers are stretched. This relieves the pressure that blocks food from passing easily into the stomach.
Most patients experience relief from their symptoms for several years following dilation. The procedure may have to be repeated. Other treatments also may be needed.
The chief risk of balloon dilation is a tear in the esophagus, which occurs in a small number of patients. This requires emergency surgery.
- Surgery (Heller myotomy). The esophageal sphincter can be opened with surgery, called myotomy. Newer surgical techniques have led to improved outcomes with shorter hospital stays and lower risks.
Myotomy can be done laparoscopically. This means telescopic equipment is inserted through small incisions in the abdomen. Most people have good to excellent results.
- Botulinum toxin. Tiny amounts of botulinum toxin are injected directly into the esophageal sphincter. This paralyzes and then relaxes the sphincter, allowing food to pass readily into the stomach.
Botulinum (Botox) is expensive, however. And its effects are relatively short-lived.
- Other medications. Drugs can be taken to reduce pressure at the esophageal sphincter. They include nifedipine (Adalat, Procardia) and nitrates (isosorbide or nitroglycerin). To be most effective, a tablet is dissolved under the tongue before meals.
Improvements with these medications are quite variable. They are seldom used as primary therapy today.
When To Call A Professional
You should call your doctor for an urgent evaluation if you:
- Experience any new chest pain, especially if it lasts for longer than five or 10 minutes
- Cannot swallow liquids
Make an appointment to see your doctor for an evaluation if you experience:
- Unexplained weight loss
- Nighttime cough or pain
- Difficulty swallowing solid food
There is no known cure for achalasia. But several treatments can provide good to excellent relief from symptoms for a number of years. When treatment needs to be repeated, it can be as successful as initial treatment.
American Academy of Family Physicians (AAFP)
American College of Gastroenterology (ACG)
American Gastroenterological Association
Society of Thoracic Surgeons
Bible verses for today’s meditation and inspiration: Matthew E. McLaren’
Then you will call on me and come and pray to me, and I will listen to you. Jeremiah 29:12 NIV
Be joyful in hope, patient in affliction, faithful in prayer. Romans 12:12 NIV
And when you pray, do not keep on babbling like pagans, for they think they will be heard because of their many words. Matthew 6:7 NIV
The Lord is near to all who call on him, to all who call on him in truth. Psalm 145:18 NIV
‘Call to me and I will answer you and tell you great and unsearchable things you do not know.’ Jeremiah 33:3 NIV
“For where two or three gather in my name, there am I with them.” Matthew 18:20 NIV
Let us then approach God’s throne of grace with confidence, so that we may receive mercy and find grace to help us in our time of need. Hebrews 4:16 NIV
who is unseen. Then your Father, who sees what is done in secret, will reward you. Matthew 6:6 NIV
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