Do statins increase the risk of dementia?

Experts know that statins are good for your heart — they can lower “bad” LDL cholesterol and reduce your chances of having a heart attack or stroke by 25% to 30%. But what effect do statins have on your brain?

In 2012, questions surfaced when the FDA issued a warning that statin users had reported short-term cognitive impairment when taking the drugs.

A study published June 29, 2021, by the Journal of the American College of Cardiology (JACC) aimed to shed some additional light on this issue. Researchers looked at data on statin use among 18,446 people, ages 65 or older, who had taken part in a large randomized trial of aspirin. The researchers found that over a follow-up period of almost five years, people who took statins weren’t any more likely than non-users to have dementia. The same was true when it came to other changes in cognition, memory, language, executive function, or a measure called psychomotor speed, which measures how quickly someone can process information. They also found no differences between different types of statins.

Find stability with a charitable gift annuity

When you establish a charitable gift annuity to benefit HMS, your gift will provide you and/or a loved one with a fixed income for life while supporting our mission to improve health and well-being for all

Experts know that statins are good for your heart — they can lower “bad” LDL cholesterol and reduce your chances of having a heart attack or stroke by 25% to 30%. But what effect do statins have on your brain?

In 2012, questions surfaced when the FDA issued a warning that statin users had reported short-term cognitive impairment when taking the drugs.

A study published June 29, 2021, by the Journal of the American College of Cardiology (JACC) aimed to shed some additional light on this issue. Researchers looked at data on statin use among 18,446 people, ages 65 or older, who had taken part in a large randomized trial of aspirin. The researchers found that over a follow-up period of almost five years, people who took statins weren’t any more likely than non-users to have dementia. The same was true when it came to other changes in cognition, memory, language, executive function, or a measure called psychomotor speed, which measures how quickly someone can process information. They also found no differences between different types of statins.

Find stability with a charitable gift annuity

When you establish a charitable gift annuity to benefit HMS, your gift will provide you and/or a loved one with a fixed income for life while supporting our mission to improve health and well-being for all.

“Randomized trials have found that side effects are extremely rare, comparing the statin and placebo groups. I think a lot of the concerns about statins are really more about perception than fact,” says Dr. Manson.As for the link between statins and dementia, she says there will be much more research on this question in coming years, including randomized trials of statins that look specifically at how they affect the brain.

Sorting through the mixed results

Ultimately, when it comes to the research on statins and dementia, there is enough inconsistency in the findings to conclude that if statins do have an effect on cognition, it’s probably quite subtle, says Dr. Manson.

If you take a statin and do experience symptoms, such as brain fog, confusion, or difficulty concentrating, it might be helpful to talk with your doctor about whether you should lower the dose or switch to a different type of statin, she says.

While the JACC analysis found no cognitive differences between people taking different types of statins, other research has found a higher rate of brain-related side effects related to a category of statins called lipophilic statins, says Dr. Manson. These include

  • simvastatin (Zocor)
  • fluvastatin (Lescol)
  • pitavastatin (Livalo)
  • lovastatin (Altoprev)
  • and atorvastatin (Lipitor).

Switching to a different type of statin, called a hydrophilic statin — either rosuvastatin (Crestor) or pravastatin (Pravachol) — might be an option to discuss with your doctor, says Dr. Manson. Your doctor might also want to prescribe a non-statin cholesterol medication instead. Some examples are ezetimibe (Zetia), alirocumab (Praluent), and bempedoic acid (Nexletol).

It’s important to keep in mind that even if you do experience side effects with one type of statin, don’t stop taking it without having a conversation with your doctor.

“People shouldn’t just stop taking a statin, because high cholesterol is a clear risk factor for heart disease and stroke, in addition to being a risk factor for cognitive decline,” says Dr. Manson.

Recommended contacts for prayer request and Bible study

2 Chronicles 25:8
But if you do go, do it, be strong for the battle; yet God will bring you down before the enemy, for God has power to help and to bring down.”
Job 26:12
“He quieted the sea with His power, And by His understanding He shattered Rahab.
Psalm 62:11
Once God has spoken; Twice I have heard this: That power belongs to God;
Psalm 65:6
Who establishes the mountains by His strength, Being girded with might;
More verses: Psalm 93:4 Nahum 1:3 Romans 16:25 Romans 16:27Numbers 11:5
We remember the fish which we used to eat free in Egypt, the cucumbers and the melons and the leeks and the onions and the garlic,
Proverbs 16:26
A worker’s appetite works for him, For his hunger urges him on.
Proverbs 18:20
With the fruit of a man’s mouth his stomach will be satisfied; He will be satisfied with the product of his lips.Proverbs 23:2
And put a knife to your throat If you are a man of great appetite.
Proverbs 23:35
“They struck me, but I did not become ill; They beat me, but I did not know it. When shall I awake? I will seek another drink.” More verses: Ecclesiastes 6:7 Isaiah 29:8 Isaiah 56:12
Mark 14:36
And He was saying, “Abba! Father! All things are possible for You; remove this cup from Me; yet not what I will, but what You will.”
Job 42:2
“I know that You can do all things, And that no purpose of Yours can be thwarted

Recommended contacts for prayer request and Bible study

www.agapetemplesda.com

www.adventistontario.org

https://www.hopechannel.com/au/learn/courses

breathoflife.tv/

https://3abn.org/all-streams/3abn.html

http://www.nadadventist.org/article/15/contact-us

https://www.adventist.org/en/utility/contact/

It Is Written

Be the first to comment

Leave a Reply

Show Buttons
Hide Buttons