The rise of computational medicine

Today, medical researchers are engaged in the controversy, or the big data revolution, wherein information is being used as a research tool rather than testing ideas through experimentation. For example, back in the 1970 decade, the polio researcher Linus Pauling attacked the cause of the sickle cell disease in blood.

In this disorder, misshapen red blood cells block small blood vessels, causing children and young adults to have recurrent bouts of excruciating pain and strokes or heart attacks. Pauling ascribed the repeated discomfort to these children and teenagers to this altered protein, globin.

The simple observation brought him up with a concrete experiment. He mixed healthy people and unhealthily afflicted people together to set up a gel. Next, he switched on an electric current that sent the globin through the gel. Healthy globin moved differently than sick globin. Anybody could see the distinction just by looks. You did not need a lab test to realize it.

For a few decades it was once possible to assume that many diseases were caused from a defective protein or another type of chemical. If so, perhaps simple cures would follow.

The end of the 1970s made it clear that inside all cells were trillions of molecules and energetic compounds, as well as proteins and nucleic acids. Genotype plays a role in most diseases associated with these molecules.

This meant that, with most diseases, one would have to analyze thousands of molecules to determine what was incorrect. However, in the 1970s, such analyses were not possible. Scientists could not identify which molecules were the afflicted ones: they could guess, like Linus Pauling did. And their guesses were often incorrect wise, but wrong.

Fortunately, the effort needed to identify all our roughly twenty thousand human genes allowed not only the accomplishment of that goal but also the establishment of technologies that analyze numerous elements of countless types. Even 30 years ago, few scientists imagined that such a wonder would ever be possible.

However, unlike Pauling’s experiment, these experiments dealing with thousands of atoms require very intricate analyses beyond mathematics in terms of cutting-edge methods to design theories from the results of these experiments. An entirely new field of study, computational medicine, was developed.

At Harvard Medical School, we have founded a thriving department dedicated to the development of innovative quantitative medicine and the training of young scientists, interns, and technicians. The advent of data science in the medical profession gave rise to yet another vital breakthrough.

Today, we don’t always need to an enticing concept to overhaul science. We can presently have the chance to figure out the difference between people and sick areas and ask what cytokines are missing. Now, it’s common knowledge that all that may be missing is no longer mysterious. We can now just sit back and watch the process.

Bible verses for today’s meditation and inspiration: Matthew E. McLaren

2 Corinthians 13:9 For we rejoice when we ourselves are weak but you are strong; this we also pray for, that you be made complete.

Colossians 1:28 We proclaim Him, admonishing every man and teaching every man with all wisdom, so that we may present every man complete in Christ.

Colossians 4:12 Epaphras, who is one of your number, a bondslave of Jesus Christ, sends you his greetings, always laboring earnestly for you in his prayers, that you may stand perfect and fully assured in all the will of God.

2 Corinthians 10:15-16 not boasting beyond our measure, that is, in other men’s labors, but with the hope that as your faith grows, we will be, within our sphere, enlarged even more by you, so as to preach the gospel even to the regions beyond you, and not to boast in what has been accomplished in the sphere of another.

2 Thessalonians 1:3 We ought always to give thanks to God for you, brethren, as is only fitting, because your faith is greatly enlarged, and the love of each one of you toward one another grows ever greater;

2 Peter 3:18 but grow in the grace and knowledge of our Lord and Savior Jesus Christ To Him be the glory, both now and to the day of eternity. Amen.

Ephesians 1:17-18 that the God of our Lord Jesus Christ, the Father of glory, may give to you a spirit of wisdom and of revelation in the knowledge of Him. I pray that the eyes of your heart may be enlightened so that you will know what is the hope of His calling, what are the riches of the glory of His inheritance in the saints,

Ephesians 3:16-19 that He would grant you, according to the riches of His glory, to be strengthened with power through His Spirit in the inner man, so that Christ may dwell in your hearts through faith; and that you, being rooted and grounded in love, may be able to comprehend with all the saints what is the breadth and length and height and depth, read more

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